In this study here, our examination of axonal enrichment of BACE1 and LAMP1 in the dystrophies at amyloid plaques revealed that the axonal organelles in AP-4 KO animals showed a stronger enrichment of BACE1 (Figs. 4F,G, 5) than those in control 5xFAD mice having normal AP-4 function while they had comparable levels of LAMP1 (Fig. 4D,E). The gene discussed is BACE1; the disease is amyloidosis.