In contrast, inflammation-mediated proliferative pathways, including the mTORC and IL6/JAK/STAT3 signaling pathways, are more upregulated in CAC.19, 20, 21, 22, 23 Consistent with the above-described negative correlation between RBBP9 expression and the mTORC and STAT3 pathways in UC samples, RBBP9 expression in CAC samples was lower than that in sCRC samples (Figure 1F), suggesting different roles of RBBP9 in the development of these 2 types of CRC. This evidence concerns the gene STAT3 and colorectal carcinoma.