CASP3 and neoplasm: In agreement with previous reports showing that the activation of the IFN/JAK/STAT1 axis induces cell apoptosis in the intestinal epithelium and organoids,8,9 the level of cleaved caspase-3 was increased in Rbbp9-/- organoids and ApcMin/+;Rbbp9-/- tumor organoids treated with IFN-γ, concomitant with increased pSTAT1 levels (Figure 6H and J).