This makes the GnRH agonist implants suitable for those owners who want to keep the decision on reproductive control open without having to perform an invasive, permanent, and irreversible surgery.1, 2 In human medicine, these implants are applied to delay early puberty in children3 and to treat androgen-dependent prostate cancer.4, 5, 6 Interestingly, GnRH slow release implants even improved cognitive function in patients with down syndrome.7 This evidence concerns the gene GNRH1 and Down syndrome.