Therefore, it appears that under oxidative stress conditions, Ngb may exert two simultaneous and opposite functions: (i) it can protect the cell by consuming ROS through heme degradation, although the existence of possible redox partners able to reduce Compound I, thus avoiding heme degradation in vivo, cannot be ruled out, and (ii) it can undergo to radical polymerization, resulting in the formation of protein aggregates [19], possibly contributing to the onset of neurodegenerative diseases. The gene discussed is NGB; the disease is neurodegenerative disease.