As observed by Zeller and colleagues, the functional effect of C allele (rs385076 NLRC4) with increase of IL-18 levels in cardiovascular disorders (Zeller et al., 2015), T allele of rs385076 was associated with autoimmune thyroid disease (Liu et al., 2020) and TT genotype with young onset of type 1 diabetes in a study conducted with Chinese population (Xu et al., 2020). Here, IL18 is linked to type 1 diabetes mellitus.