PPARGC1A and diabetes mellitus: Our data show that diabetes suppressed the expression of proteins associated with FAO such as carnitine palmitoyltransferase 1a (CPT1a), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), and sirtuin 3 (SIRT3) in the kidneys from diabetic control mice but not in the kidneys from Angplt4−/− mice (Fig. 2A).