DCA, 2-DG, Ac-SDKP, Ac-SDKP + ACEi, ACEi, and fenofibrate significantly suppressed fibrosis and Angptl4 expression, suggesting that blockade of kidney-specific Angptl4 could be an important strategy in the management of DKD (fig. This evidence concerns the gene ANGPTL4 and diabetic kidney disease.