Our data indicate that YAP1 expression in the cancer cells causes increased infiltration of MDSCs in the TME and induces the polarization of macrophages into M2 phenotype (Figure 4E and Figure 5, D–F), and RT-qPCR analysis revealed that genetic or pharmacological YAP1 attenuation downregulates the expression of PD-L1 in in vitro conditions (Supplemental Figure 8, A and B). The gene discussed is CD274; the disease is cancer.