The reduction of tumor growth was also observed in mice xenograft models after injecting HCT116 cells with downregulated expression of PHLDA1. Finally, the group of Duan et al. presented PHLDA1 as an activator of RAS/MAPK signaling in pancreatic adenocarcinoma as a result of examining the GSCALite database (Duan et al. 2022). The gene discussed is PHLDA1; the disease is neoplasm.