Moreover, Bugara et al. performed quantitative proteomic analysis of PHLDA1-silenced IMR-32 neuroblastoma cells, which revealed the most pronounced changes in mitochondrial proteome as compared to control cells, established by gene ontology annotation analysis using the DAVID 6.8 platform (Wei Huang et al. 2009; Bugara et al. 2024). The gene discussed is PHLDA1; the disease is neuroblastoma.