After chronic stress, the level of Sp1 Transcription Factor (SP1) in TDEs increased, facilitating neutrophil secretion of Interleukin 1 Beta (IL‐1β) through the Toll‐Like Receptor 4 (TLR4)‐Nuclear Factor Kappa B (NFκβ) pathway, which created an immune‐suppressive microenvironment and aggravated breast cancer lung metastasis. The gene discussed is TLR4; the disease is breast carcinoma.