Acute stress redistributes leukocytes in mice, including neutrophils, monocytes, B cells, and T cells.[35] In a non‐tumor‐bearing background, chronic stress affects lung function and regulates the expression levels of immune‐related genes.[36] Further gene editing of Rab27a in the 4T1 cells should be conducted to elucidate the extent to which chronic stress‐induced TDEs remodel the lung immune microenvironment. Here, RAB27A is linked to neoplasm.