KL and diabetic kidney disease: It has been reported that α‐klotho (KLA), another klotho protein, could protect against diabetic kidney disease by promoting the phosphorylation of AMPK, a central regulator of energy homeostasis.[56] Our study observed a diminishment of KLA in DKD patients, DKD mice, and HGL‐cultured HK‐2 cells, which can be restored by Smg (Figure S5D–G, Supporting Information).