KLB and Cognitive impairment: Fourthly, KLA can also repress the WNT‐β‐catenin signaling involved in DKD‐associated epithelial‐mesenchymal transition, collagen accumulation, kidney fibrosis, and vascular calcification.[88, 89, 90] The potency of KLA in ferroptosis inhibition has been reported in cognitive deficit models.[91] Although the transcriptomic analysis did not screen out KLA in HK‐2 cells, this did not exclude the possibility that KLA could also exert a renal protection function similar to KLB.[56, 57] In other words, Smg may alleviate renal injury in DKD patients by upregulating both KLA and KLB.