Regarding the effect of GLP‐1RAs on renal inflammation and fibrosis by inhibiting ferroptosis, previous studies have reported that GLP‐1RA liraglutide attenuated systemic inflammation[76] and renal fibrosis in DKD.[77] In the present study, we observed activation of the NFκB and TGF‐β1/Smads signaling pathways, along with elevated expression levels of pro‐inflammatory factors (IL‐1β, TNF‐α, IL‐6, and MCP‐1) and fibrotic proteins (α‐SMA, Vimentin), while Ecad was reduced. This evidence concerns the gene ACTA1 and renal fibrosis.