Regarding the effect of GLP‐1RAs on renal inflammation and fibrosis by inhibiting ferroptosis, previous studies have reported that GLP‐1RA liraglutide attenuated systemic inflammation[76] and renal fibrosis in DKD.[77] In the present study, we observed activation of the NFκB and TGF‐β1/Smads signaling pathways, along with elevated expression levels of pro‐inflammatory factors (IL‐1β, TNF‐α, IL‐6, and MCP‐1) and fibrotic proteins (α‐SMA, Vimentin), while Ecad was reduced. The gene discussed is ACTA1; the disease is diabetic kidney disease.