As shown in Figure S8C–F (Supporting Information), the overexpression of Klb not only elevated the level of KLB in both NC and DKD mice, but also significantly increased the phosphorylation of LKB1, AMPK, and ACC1, along with the expression of SIRT1, NRF2, SLC7A11, GPX4, and FSP1. This evidence concerns the gene SIRT1 and diabetic kidney disease.