The persistence of an antitumor immune response is orchestrated by the enduring presence of CD8+ progenitor‐exhausted T (TPEX) cells, which function as a critical resource for the replenishment of effector T cells and ensure their abundance through self‐renewal.[58] Research by Huang and colleagues has uncovered that tumor‐specific TPEX cells arise from a lineage of TTSMcells. The gene discussed is CD8A; the disease is neoplasm.