TNF and neoplasm: TEX‐int is a transitional state between TPEX and TEX,[64, 65, 66, 67] and it has been shown to possess superior functional capabilities compared to TEX, including the secretion of higher levels of IFN‐γ, TNF‐α, and IL‐2.[65, 68, 69] This discovery underscores the notion that the combined treatment can transform the tumor microenvironment, shifting “cold” tumors to “hot” tumors, thereby heralding a promising strategy in immunotherapy.