HIF1A and colorectal carcinoma: In this study, a novel “Three‐in‐One” Cu‐PrIm nanozymes with peroxidase (POD)‐like activity has been developed, which could promote colorectal cancer (CRC) cell death via apoptosis and cuproptosis, and facilitate hypoxia‐inducible factor 1α (HIF‐1α) degradation leading to reversal of chemoresistance.