GRP78, also named BIP or HSP5A, is a multifunctional protein with diverse activities beyond its well‐established role in the unfolded protein under ER stress.[40] As an oncogene, GRP78 is critically involved in the survival, proliferation, and development of chemoresistance in tumor cells across a range of cancers, including ovarian cancer,[41] breast cancer,[42] prostate cancer,[43] and colorectal cancer.[44] In the study, we revealed that binding to GRP78 is responsible for lnc191 to promote ESCC progression in vitro and in vivo. This evidence concerns the gene HSPA5 and colorectal cancer.