HSPA5 and liver cancer: However, in cancerous cells, GRP78 is also observed in various cellular compartments, including the mitochondria, cytosol, nucleus, and cell surface.[45] Notably, GRP78 is abnormally localized on the surface of numerous cancer cells, such as those found in the lung, breast, colon, AML, and liver cancers, while its expression is rare in normal cells.[46, 47, 48, 49] This aberrant localization offers a promising avenue for tumor‐specific therapeutic strategies and targeted drug delivery, minimizing damage to healthy tissues.