Mechanistically, lnc191 interacts with GRP78 (78‐kDa glucose‐regulated protein), one of the endoplasmic reticulum chaperone proteins, leading to its translocation to the membrane, where GRP78 binds with EGFR and enhances its phosphorylation (Y845), further activates ERK/MAPK signaling pathway, and thereby in favor of the progression of ESCC. Here, EGFR is linked to esophageal squamous cell carcinoma.