Moreover, accumulating evidence suggests that cell surface GRP78 (csGRP78) enhances cancer aggressiveness and has been identified as a potential target or anticancer intervention.[46, 50] As a receptor involved in cell surface signaling, csGRP78 can be activated by multiple ligands, leading to the activation of various downstream signaling pathways that regulate cancer cell proliferation, survival, and apoptosis.[51] In this study, we observed that lnc191 interacts with GRP78 and facilitates its translocation to the cell membrane. This evidence concerns the gene HSPA5 and cancer.