While p53 is not the only substrate acetylated by HATs, its acetylation is influenced by different factors, such as changes in protein structure, protein‐protein interactions, and various physiological or pathological conditions.[18] Therefore, it remains poorly understood whether p53 acetylation is associated with prognosis and how p53 acetylation is regulated in GBM. This evidence concerns the gene TP53 and glioblastoma.