Stroke, resulting from an acute blockage of cerebral blood flow, is the second leading cause of mortality worldwide.[1] Approximately 85% of stroke cases are ischemic strokes, which lead to rapid neuronal death from insufficient blood supply.[2] Thrombolysis and thrombectomy are the two main treatments for ischemic stroke.[3] Thrombolysis is an emergency treatment that uses medications such as tissue plasminogen activator to restore blood flow by dissolving blood clots. This evidence concerns the gene PLAT and Stroke.