TGFB1 and Marfan syndrome: Additionally, in healthy conditions, these microfibrils act as a reservoir of transforming growth factor beta (TGF‐β), hence Marfan syndrome also results in dysregulated TGF‐β signaling.[7] Marfan syndrome mainly affects the skeleton, eyes, and cardiovascular tissues but can also affect many other systems, as the connective tissues are widespread in the body.[6]