The aberrant TME remodeling occurring at tumor sites also influences TGF‐β and Wnt/β‐catenin‐mediated signaling pathways, favoring the extracellular retention of soluble factors TGF‐β and Wnt (Figure 4B).[42, 55] Upon activation, these pathways serve a dual role. Here, TGFB1 is linked to neoplasm.