Recently, it was shown that the codelivery of lipid NPs (LNPs) carrying FAK siRNA and CRISPR‐PD‐L1 effectively reduced ECM deposition and stiffening of cancer cells, thus increasing transfection efficiency and resulting in knock‐down of immune checkpoint protein programmed death ligand 1 (PD‐L1) (Figure8A).[25a] The LNPs were constructed using ionizable lipid 5A2‐SC8, cholesterol, 1,2‐dioleoyl‐sn‐glycero‐3‐phosphoethanolamine, 1,2‐dimyristoyl‐rac‐glycero‐3‐methoxy‐poly(ethylene glycol)‐2000 (DMG‐PEG2000), and DSPE‐PEG2000 at a molar ratio of 15:30:15:2:1. The gene discussed is CD274; the disease is cancer.