The PSMA density exhibited a strong negative correlation with cell survival probability in all tissue samples, particularly in tumor cell-abundant regions in both [225Ac]Ac- (PC1: Spearman ρ = -0.76, p<0.0001, PC2: Spearman ρ = -0.68, p<0.0001, PC3: Spearman ρ = -0.66, p<0.0001) and [177Lu]Lu-PSMA-targeted RPT simulation (PC1: Spearman ρ = -0.76, p<0.0001, PC2: Spearman ρ = -0.59, p<0.0001, PC3: Spearman ρ = -0.64, p<0.0001) (Figure 5A). The gene discussed is FOLH1; the disease is neoplasm.