CD274 and neoplasm: Tumor cells typically create an immunosuppressive environment by recruiting immunosuppressive cells 11, 12, secreting factors that suppress the immune response 13-16, overexpressing antigens like PD-L1 17, 18, exhibiting low major histocompatibility complex (MHC) 19, 20, or releasing tumor exosomes to sustain their survival and progression 21, 22.