Other large-scale chromosomal events in PCa involve amplification of regions 8q and Xq and more commonly deletions in regions 8p, 10q, 13q, and 17p; these regions encompass genes that are strongly linked to PCa progression, including the AR gene, the MYC oncogene, and tumor suppressors PTEN and TP5335, 41. Here, MYC is linked to posterior cortical atrophy.