PTEN and posterior cortical atrophy: Other large-scale chromosomal events in PCa involve amplification of regions 8q and Xq and more commonly deletions in regions 8p, 10q, 13q, and 17p; these regions encompass genes that are strongly linked to PCa progression, including the AR gene, the MYC oncogene, and tumor suppressors PTEN and TP5335, 41.