These findings indicate that IFN-γ from tumor-specific CD8 T cells, possibly combined with that from endogenous lymphocytes, activates STAT1 signaling in the tumor endothelial cells as early as Day 1.5 following T cell transfer, whereas IFN-γ effects are limited on the cells more distant from the vessels even at later time points. This evidence concerns the gene IFNG and neoplasm.