CXCL9 and CXCL10 are well known IFN-γ-inducible chemokines produced by endothelial cells, monocytes/macrophages and fibroblasts in the tumor microenvironment and prevent tumor angiogenesis by blocking endothelial cell proliferation, inducing tumor necrosis 32-35. This evidence concerns the gene CXCL9 and neoplasm.