IFNGR1 and neoplasm: To discern which non-tumor cells expressing IFN-γR1 are the main target of IFN-γ, we utilized Tie2creIFNγR1flox/flox mice, lacking IFN-γR1 in both endothelial and some of hematopoietic-lineage cells (mainly myeloid cells) 19, 20, alongside their corresponding control IFNγR1flox/flox littermates that express IFN-γR1 on all cells.