It is possible that the interaction time between tumor-specific T cells and tumor vascular endothelial cells is longer than that with endothelial cells in normal organs, due to complex mechanisms; involving chemokine-mediated recruitment and augmented adhesion of activated T cells to inflamed tumor vascular endothelial cells, presence of tumor-associated high endothelial venules that enhance recruitment and transendothelial extravasation of T cells, and tumor-antigen expression by endothelial cells in the context of MHC, which can be recognized by tumor-specific T cells 28-30. The gene discussed is HLA-C; the disease is neoplasm.