This study expands on BATF2's role in gastric cancer, demonstrating how it interacts with PTEN to suppress the AKT/β-catenin/ABCG2 signaling pathway, impacting stem cell markers like ABCG2, CD44, SOX2, and NANOG, based on in vivo and in vitro analyses. This evidence concerns the gene ABCG2 and gastric cancer.