HNF4A and hepatocellular carcinoma: In this study, we analyzed the databases from LIHC of TCGA, GEO (GSE128683, GSE182593), Liver Cancer Model Repository (LIMORE), and Liver Cancer Organoid Biobank (LICOB) and discovered that the lipid metabolism-related and relatively liver-specific lncRNA HNF4A-AS1 is underexpressed in HCC and associated with sorafenib resistance.