Similarly, in our investigation, we observed that overexpression of DECR1 diminished sorafenib-induced ferroptosis in HCC cells, and this process was rescued by supplementing exogenous PUFA (DHA or DPA), as determined by cell viability, LPO, MDA, and GSH (Figure S4H-J). This evidence concerns the gene DECR1 and hepatocellular carcinoma.