To further investigate the impact of HNF4A-AS1 on the sorafenib response in HCC in vivo, we performed subcutaneous xenografts with HCC cells stably transfected with Lv-lnc-HNF4A-AS1 or Lv-sh-HNF4A-AS1 in nude mice (Figure 9A). This evidence concerns the gene HNF4A and hepatocellular carcinoma.