Our previous study found noteworthy differences in immune cell profiles between MDD patients and healthy controls (HC), including increased proportions of CCR2+ CD8T cells, Trem1+ monocytes, IgD+ memory B cells, and plasmablasts, as well as decreased levels of Tregs, follicular T cells, gamma-delta T cells, Th17 cells, naïve CD4 T cells, and CD4 T cells 14. The gene discussed is CD4; the disease is major depressive disorder.