IL-13 and IL-4 share the same receptor subunit, the IL-4Rα chain, and IL-4Rα/IL-13Rα1 activates STAT6 via the JAK-STAT signaling cascade or tyrosine kinase 2, which in turn drives skin inflammation (Bieber, 2020; Newsom et al., 2020). This evidence concerns the gene IL4R and dermatitis.