However, the once-weekly insulin intervention only affected the insulin-naïve type 2 diabetic population (MD −0.20%; 95% CI −0.30 to −0.09%; I2 = 48%; p = 0.0002), and no effect was detected in type 1 diabetes (MD 0.11%; 95% CI −0.02 to 0.23%; I2 = 0%; p = 0.11) or type 2 diabetes (MD −0.08%; 95% CI −0.25 to 0.08%; I2 = 69%; p = 0.31), which were previously treated with insulin. The gene discussed is INS; the disease is type 2 diabetes mellitus.