When assessed separately, patients with insulin-naïve type 2 diabetes (MD 0.45 kg; 95% CI 0.13 to 0.77 kg; I2 = 0%, p = 0.006) or treated with icodec (MD 0.54 kg; 95% CI 0.26 to 0.81 kg; I2 = 4%, p = 0.0001) had a significant weight gain compared to once-daily insulin (Supplementary Figures 5A, B). The gene discussed is INS; the disease is type 2 diabetes mellitus.