VEGFA and neoplasm: Tumor angiogenesis is a complex biological process affected by various signaling pathways, such as hypoxia induction factor pathway (HIF) (31), vascular endothelial growth factor pathway (VEGF) (32), fibroblast growth factor pathway (FGF) (33), PI3K/Akt pathway (34), Ras/Raf/MEK/ERK pathway (35), Notch signaling pathway (36), transforming growth factor- β pathway (TGF- β) (37), Wnt/β -catenin pathway (38), these pathways are interwoven and synergistic, determine the dynamic balance of tumor angiogenesis.