Since rutin has poor absorption in the body, we chose ferulic acid, luteolin, and quercetin to verify their anticancer activity in NSCLC cells such as A549 (EGFR wild type), PC9 (EGFR mutant without T790M), and H1975 (EGFR mutant with T790M). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.