Mutation in neuraminidase 1, NEU1 (sialidase 1), a lysosomal enzyme that plays a crucial role in the catabolism of sialo-glycoconjugates, leads to lysosomal storage disorder sialidosis, while abnormal NEU1 activity has been implicated in cancer progression, inflammation, and immune response (102, 103). This evidence concerns the gene NEU1 and sialidosis.