Mutation in neuraminidase 1, NEU1 (sialidase 1), a lysosomal enzyme that plays a crucial role in the catabolism of sialo-glycoconjugates, leads to lysosomal storage disorder sialidosis, while abnormal NEU1 activity has been implicated in cancer progression, inflammation, and immune response (102, 103). This evidence concerns the gene NEU1 and lysosomal storage disease.