Intriguingly, it was reported that miR-99a-5p overexpression enhances sensitivity to cisplatin (DDP) and cell apoptosis by suppressing VLDLR expression in lung cancer cells (Lang et al., 2023), and miR-99a inhibits two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer (Feliciano et al., 2017). Here, E2F2 is linked to lung cancer.