PCSK9 and cancer: Although miR-337-3p (Xu X. et al., 2021), miR-483 (Dong et al., 2020) and miR-552-3p (Ma et al., 2021) have been identified to reduce serum LDL-C level in mice by targeting PCSK9, miR-483 and miR-552-3p have been found to stimulate cell proliferation, migration and invasion of cancer (Song et al., 2014; Huang et al., 2021).