A study by Huang et al. in a mouse model of silicosis emphasizes NAC’s effectiveness in reducing oxidative markers such as malondialdehyde (MDA) and boosting antioxidant defenses like superoxide dismutase (SOD) activity and glutathione levels, suggesting that NAC’s action in reducing oxidative stress likely contributed to the mitigation of lung inflammation and lung fibrosis in the mouse model study, where the reduction of oxidative stress was crucial [19]. This evidence concerns the gene SOD1 and silicosis.