CD274 and carcinoma: The PD-L1 test (SP142, Ventana) resulted in a positive IC score of 10%. Invasive carcinoma of the breast with medullary features with HER2 Dual In Situ Hybridization was negative for HER2 amplification (HER2 gene average signals 2 .0 and Chr17 average signals 2.0, with ratio of 1.0).