CD4 and neoplasm: Since malignant tumors are characterized by genomic, phenotypic, and antigenic diversities, we can infer that lethal damage may be selective, explaining cell modulation during tumor evolution [10,11]. We should also emphasize that, in the relationship between the immune system and the tumor, innate immunity composed of natural killer cells, eosinophils, basophils, and phagocytic cells, is dominant mainly over adaptive immunity integrated by B, T, CD4, and CD8 lymphocytes.