CD8A and cancer: Interestingly, a strain of L. lactis is a promising candidate for potentiating cancer treatment in combination with current standard therapy as it was found to inhibit tumor growth by regulating tumor angiogenesis and directly inducing cancer cell death; moreover, it can enhance the therapeutic effects of oxaliplatin and the PD-1 blockade, by augmenting cytotoxic immune cell populations, such as CD4+ T cells, CD8+ effector T cells, and NK cells in the tumor microenvironment [75].