The facilitation of the in situ delivery of the anti-inflammatory IL-10 cytokine by the use of genetically engineered strains of L. lactis seems to be efficient as a therapy to treat low-grade colon inflammation [78] and food-induced IgE sensitization [79], as it attenuated intestinal inflammation in IL-10-deficient mice [80] and reduced inflammation in a murine model of experimental colitis [81]. The gene discussed is IGHE; the disease is colitis.