Similarly, other strains of L. lactis also showed a potential role in the treatment of IBD by an anti-inflammatory effect, as they were able to reduce IL-1β-induced IL-8 secretion in vitro in Caco-2 cells, suggesting a potential anti-inflammatory effect, while oral treatment with this LAB resulted in a milder form of recurrent colitis than that observed in control diseased mice [71]. The gene discussed is IL1B; the disease is colitis.