For instance, three independent variants (rs2981578, rs35054928, and rs45631563) in fibroblast growth factor receptor 2 (FGFR2) were mapped to transcriptional silencer elements, enhancing silencer activity, reducing FGFR2 expression, and increasing breast cancer risk due to greater estrogen responsiveness 31. Here, FGFR2 is linked to breast carcinoma.