HMGB1 and Increased total leukocyte count: Houttuyniae Herba has been explored as a potential therapeutic agent because of its anti-inflammatory properties.10, 12, 28, 29 It reduces leukocytosis, lowers pro-inflammatory cytokine levels, and downregulates MAPK and NFκB pathways.28, 29 Perillae Folium effectively inhibits the inflammatory response by deactivating the HMGB1 signaling pathway and significantly suppresses the production of cytokines such as TNF-α and/or IL-6.30, 31.