However, the roles of SLC41A1 in HCC was opposite to those in human pancreatic ductal adenocarcinoma, where SLC41A1 was downregulated and inhibited proliferation, migration and invasion through magnesium-dependent Akt/mTOR inhibition and bax-regulated apoptosis 10. The gene discussed is SLC41A1; the disease is pancreatic ductal adenocarcinoma.