The primary objective was to examine the correlation between platelets and various immune cell populations, including CD3−CD19+ B-cells, different T-cell subsets (CD3+CD4+ T-cells, CD3+CD8+ T-cells, double-negative T-cells (DN T-cells), regulatory T-cells (Tregs)), and CD3−CD16+CD56+ natural killer (NK) cells, within the context of moderate COVID-19 cases exhibiting AHL platelet levels and normal platelet levels during recovery. This evidence concerns the gene CD8A and COVID-19.