Among the protein-coding genes causally associated with unspecified asthma in lung and blood, seven are within the 17q12-21 locus (i.e., PGAP3, IKZF3, GSDMB, ORMDL3, GSDMA, MED24, and CASC3; Supplementary Figure S3). Here, IKZF3 is linked to asthma.