Lipoprotein(a) [Lp(a)] consists of an LDL-like particle containing apolipoprotein B100 that is covalently bound to apolipoprotein(a).62 While elevated Lp(a) is associated with increased risk of coronary artery disease and ischemic stroke, the causal nature of these relationships remains unclear.62 Given that Lp(a) levels are largely genetically determined, this phenotype presents an ideal candidate for drug target MR studies. This evidence concerns the gene LPA and ischemic stroke.