F11 and ischemic stroke: In 2023, we re-evaluated the association of genetically proxied FXI inhibition using larger genetic datasets for Factor XI (from the DeCODE cohort79) and ischemic stroke (GIGASTROKE), as well as a broader set of safety outcomes including lifespan and multiple bleeding outcomes with much large sample sizes.80 This analysis replicated the prior finding of a protective association of FXI inhibition on risk of ischemic stroke and CES (OR 0.78, 95% CI 0.72–0.84).