proxied genetic inhibition of ANGPTL3, ANGPTL4, APOC3, and LPL using cis variants associated with either circulating levels of the respective protein or with triglyceride levels in UK Biobank.61 These proxies were tested for associations with multiple cardiovascular outcomes which included overall ischemic stroke risk in GIGASTROKE. This evidence concerns the gene ANGPTL3 and ischemic stroke.