GIPR and ischemic stroke: investigated the association of genetically proxied glucose-dependent insulinotropic polypeptide (GIP) signaling on various cardiometabolic outcomes including ischemic stroke (MEGASTROKE).114 Genetic proxies in the GIP and GIPR genes were identified based on statistical associations with type 2 diabetes (p < 5 × 10−6) and concordant associations with glycated hemoglobin (p < 0.05).