LPA and ischemic stroke: investigated the association of genetically proxied Lp(a) levels with ischemic stroke and other cardiovascular outcomes in the UK Biobank.63 Genetic variants in LPA were selected based on their strong association with circulating Lp(a) levels in the CHD Exome+ Consortium.64 Genetically proxied increases in Lp(a) were associated with elevated ischemic stroke risk (4,602 cases).