MAN2B1 and infection: Conversely, Nathan J. Hare et al. [46] observed a divergent outcome in human macrophages infected with M. tuberculosis. Utilising LC–MS/MS and QPCR assays, they identified several N-glycosylation-modified enzymes, noting a four-fold decrease in MAN2B1 protein levels and a significant reduction in transcript levels 72 hours post-infection.