While a PTEN knockout and constitutively active Braf transgenic mouse model (Dct-CreER KI;Braf-CA;Pten-fx/fx) has been shown to develop acral nevi and melanoma after exposure to ionizing radiation and tamoxifen, this system only models BRAF-mutated AM [11], which comprises at most 10–20% of AM [1, 3, 5]. The gene discussed is PTEN; the disease is melanoma.