Mutations or insufficiencies in ATP6AP1 are associated with an array of V-ATPase-related disorders, encompassing immunodeficiency with hepatopathy, neurological features, distal renal tubular acidosis, and cancer [22–24], underscoring its indispensable role in autophagy through the maintenance of an acidic milieu within lysosomes [25]. This evidence concerns the gene ATP6AP1 and cancer.