Moreover, Pdpn+ Mφs notably increased the levels of phosphorylated eNOS (p-eNOS/eNOS) and nitric oxide (NO), indicating that Pdpn+ Mφs significantly attenuated the dysfunction of the NO pathway in the diabetic aortae cocultured with T2DM-PV-adipocytes (Aorta&adipo&Pdpn + Mφ) (Fig. 5C, D). Here, NOS3 is linked to type 2 diabetes mellitus.