We found that Pdpn+ Mφs significantly increased the phosphorylation level of endothelial nitric oxide synthase (p-eNOS/eNOS) in the aorta with PVAT (PVAT-aorta) isolated from T2DM rats, indicating enhanced eNOS activity (Fig. 4C, D). Here, PDPN is linked to type 2 diabetes mellitus.