TNF and type 2 diabetes mellitus: We found that the expression of proinflammatory cytokines (TNF-α, IL-6, and MCP-1) and vasocontractile adipokines (resistin and AngII/AGT) was significantly increased in insulin-treated IR-3T3 cells (INS&IR-3T3) and insulin-treated T2DM-PV-adipocytes, whereas the expression of anti-inflammatory cytokine (IL-10) and vasorelaxant adipokines (adiponectin and omentin) was significantly decreased (Fig. 6F, G).