Furthermore, Pdpn+ Mφs significantly reduced the expression of proinflammatory cytokines (TNF-α, IL-6, and MCP-1) and increased the expression of the anti-inflammatory cytokine (IL-10) in PVAT-aorta isolated from T2DM rats (Fig. 4G). The gene discussed is PDPN; the disease is type 2 diabetes mellitus.