APP and Alzheimer disease: Decreased levels of ADAM10 (α-secretase) found in AD-EVs may contribute to Aβ aggregation as ADAM10 cleaves APP into a neuroprotective sAPPα isoform (as discussed for let-7 miRNAs targeting ADAM10 in Sect. “Dysregulation of RNAs in EVs from human plasma and serum samples in AD.”)[25].