For instance, long-term but minimal use of inhibitors targeting the Activin-ACVR1-SMAD1 pathway, with the addition of BMP-9 inhibitors at the onset of flare-up signs, and the use of rapamycin when cartilage formation is detected, could offer a promising avenue for effective FOP treatment. This evidence concerns the gene GDF2 and fibrodysplasia ossificans progressiva.