In addition to the NTF3 and PRKCG genes of the MAPK pathway, the HTR7 gene, which is decreased in AD, was upregulated, while ANGPT2, GAB2, INSR, MET, PDGFD, and SHC3, which increase the risk of developing the disease50–56, were downregulated. This evidence concerns the gene PDGFD and Alzheimer disease.