The mice that hepatocyte-specific knockout of D2 were resistant to HFD-induced obesity, hypertriglyceridemia, and liver steatosis.86 Recently, they found that the overall chromatin accessibility was reduced in D2 insufficient mouse which was in line with increased DNA methylation.416 Alharthi et al. reported that membrane-bound O-acyltransferase domain containing 7 (MBOAT7) reduced the accessible of inflammatory-related chromatin in COVID-19 and metabolic-associated fatty liver disease. The gene discussed is MBOAT7; the disease is fatty liver disease.