YBX1 and Hepatic fibrosis: Pharmacologic inhibition of H3K9ac or knockout of KAT2A alleviated biliary fibrosis in vivo.125 Besides, Tang et al. demonstrated that the expression of YBX1 was increased in several liver fibrosis models, and aggravated CCl4-induced liver fibrosis through activating hPSCs and extracellular matrix deposition.