CD8A and hepatocellular carcinoma: As a TF, ETV4 promoted the transcription of DVL2.144 Additionally, HBV infection reduces the expression of DDX5 to increase the chromatin accessibility and expression of multiple genes involved in Wnt signaling pathway in HCC cells.373 Besides, the HBV-induced differentiation of CD8+ T cells can be primed by Kupffer cells or hepatocytes, but the latter possesses negligible immune activity.