NASP and hepatocellular carcinoma: Further, they found that insufficient of CHD8 reduced functional synapses and leaded to reduced spontaneous firing rates in neurons.458 NASP is a histone-binding protein occurring in two major forms, sNASP and tNASP which is expressed in somatic cells or testis and embryonic tissues, respectively.459 It has reported that NASP regulates chromatin accessibility in HCC cells.147 Recently, Zhang et al. identified a nonsense mutant of NASP (tNASP-Q289X) in a Chinese nuclear family with ASD.