Loss of HNF4α decreases the recruitment of GR to GRE by reducing chromatin accessibility which consequently remodels the expression of GCs-responsive genes.297 ANGPTL4 increases the transportation of triglycerides from white adipose tissue to liver, participating in hypertriglyceridemia and hepatic steatosis.298 Koliwad et al. indicated that ANGPTL4 was a direct target of GR. The gene discussed is NR3C1; the disease is fatty liver disease.