Wahl et al. revealed that SATB2 remodeled the chromatin 3D structure and accessibility both independent and in cooperation with CTCF in cortical neurons.189 Additionally, many researches have indicated that the feature of chromatin 3D structure and accessibility were distinct in different diseases, such as breast cancer,190 glioma,191 and Alzheimer’s disease (AD).192 It indicates that the chromatin 3D structure could be an potential disease biomarker and therapeutic target. Here, SATB2 is linked to Alzheimer disease.