NASP knockdown decreased H3K9me1 modification and enhanced chromatin accessibility globally which induced the expression of tumor suppressor BACH2 and RunX1T1 to induce replication defect and enhance apoptosis of HCC cells.147 The nuclear matrix protein hnRNPU participates in three-dimensional architecture maintenance of hepatocyte genome.354 Xu et al. demonstrated that lncRNA RP11-386G11.10 enhanced lipid accumulation by upregulating hnRNPU, promoting the proliferation and metastasis of HCC cells. The gene discussed is NASP; the disease is hepatocellular carcinoma.