The POU and ETS factors binding motifs were enriched in iCCA while that of nuclear receptors were enriched in HCC.358 Besides, Li et al. found that the expression of microfibrillar-associated protein 5 (MFAP5), a ECM glycoprotein, was increasesed in intrahepatic cholangiocarcinoma (iCCA) tissues compared with para-carcinoma tissues. This evidence concerns the gene MFAP5 and hepatocellular carcinoma.