Active DNA-dependent ATPase A Domain inhibitor (ADAADi) is the first identified inhibitor directly targeting SWI/SNF catalytic activity.490 It has been reported to suppress the progression of many cancers.491,492BRM014, an allosteric ATPase inhibitor of SMARCA2/4 varying the chromatin accessibility very rapidly.493FHD-286, another allosteric inhibitor of SMARCA2/4, has been showed to inhibit AML.494. The gene discussed is SMARCA2; the disease is acute myeloid leukemia.