Zhang et al. demonstrated that inhibiting HDAC2 reduced the chromatin accessibility of HDAC2/NuRD binding motifs in HDAC1-deficient neuroblastoma.62 Price et al. revealed that DLX1 recruited NuRD by interacting with RBBP4/7 to reduce the chromatin accessibility and expression of Olig2 during subpallium development.63 Chanda et al. indicated that NO synthase-induced NO promoted the S-nitrosylation of MTA3 to decrease NuRD activity. The gene discussed is HDAC2; the disease is neuroblastoma.