Although applying PFI-3 alone has limited effect on some cancer cells, it significantly sensitized of these cancer cells to chemotherapy.495,496PB16 and GNE-235 are two promising PBRM1 selective inhibitors, but their biological function remains to be elucidated.497,498 BRD7 and BRD9, assembled into different SWI/SNF complexes, contain Family IV bromodomains.499 BRD9 or BRD7 is considered as oncogene or tumor suppressive, respectively,500,501 thus more studies are focused on targeting BRD9. The gene discussed is PBRM1; the disease is cancer.