OTX2 and hepatocellular carcinoma: MDIG has been confirmed to promote the regeneration of damaged liver by remolding the H3K9me3 modification and chromatin accessibility of OTX2.151 Additionally, researches indicated that the expression of MDIG was usually higher in HCC tissues than normal ones and promoted the growth, metastasis, and drug resistance of HCC cells by promoting the expression of p21 and cell division cycle 6 (CDC6) in a H3K9me3 demethylation-dependent manner.356,357