TNF and hepatocellular carcinoma: The DNMT and EZH2 inhibitors significantly decreased the global promoter DNA methylation and increased the chromatin accessibility, which strongly promoted the expression of immune response and interferon-stimulated genes.77 Zhang et al. reported that WD40 repeat-containing protein 6 (WDR6) reprogrammed the tumor immune microenvironment by increasing the expression of TNF-α to promote the growth and metastasis of HCC.