SMARCA2 and cancer: Panditharatna et al. constructed an ATPase degrader by linking a SMARCA4 ATPase inhibitor to a phthalimide, called JQ-dS-4, facilitating ubiquitin E3 ligase CRBN-mediated degradation, which suppressed the progression of glioma.506ACBI1 and AU-15330 are two PROTACs that link the Family VIII bromodomains with E3 ligase VHL to promote the degradation of SMARCA2/4, and PBRM1.507,508A947 and PRT3789 selectively degrade SMARCA2 to suppress SMARCA4 mutant solid tumors.509,510GSK39,511dBRD9,512C6,513CFT8634,514 and FHD-609515 are CRBN-based PROTACs for BRD9, all of which showed anti-cancer activity.