et al. indicated that Vitamin D remodeled chromatin accessibility landscape by orchestrating the interaction of BRD7 and BRD9 binding with BAF chromatin remodeling complexes to protect β cells.479 Through genome-wide accessibility studies, many T2D-associated variation loci have been screened out in human,480 but their role in T2D is required investigation. This evidence concerns the gene BRD9 and type 2 diabetes mellitus.