Although applying PFI-3 alone has limited effect on some cancer cells, it significantly sensitized of these cancer cells to chemotherapy.495,496PB16 and GNE-235 are two promising PBRM1 selective inhibitors, but their biological function remains to be elucidated.497,498 BRD7 and BRD9, assembled into different SWI/SNF complexes, contain Family IV bromodomains.499 BRD9 or BRD7 is considered as oncogene or tumor suppressive, respectively,500,501 thus more studies are focused on targeting BRD9. This evidence concerns the gene BRD9 and neoplasm.