It interacted with TEA domain TF 1/4 (TEAD1/4) to enhance the regional DNA demethylation and H3K27ac of Yes1-associated transcriptional regulator (YAP)-derived genes.81 Deng et al. found that RNA m6A modification were inversely correlated with DNA 5mC modification both in normal and cancer cells. This evidence concerns the gene YAP1 and cancer.