Among the verified genes, Jag2 was a key gene that accountable for ARID1A deficiency induced stemness of HCC cells.50 HBV infection can hijack the gene expression system of host to ensure viral gene expression and replication, such as inhibiting the expression of RNA helicase DDX5.372 The HBV-induced expression of miR106b~25 and miR17~92 directly targeted the 3′UTR of DDX5 to suppress its expression. This evidence concerns the gene DDX5 and hepatocellular carcinoma.