They confirmed that the reduced expression of DNMT chaperone ubiquitin-like, containing PHD and RING finger domains 1 (UHRF1) contributed to the variation.79 Guo et al. also indicated that UHRF1 recruited to the promoter of miR-26b to increase its DNA methylation, leading to reduced chromatin accessibility and miR-26b expression in abdominal aortic aneurysm.80 The gene discussed is UHRF1; the disease is abdominal aortic aneurysm.