YAP1 and hepatoblastoma: The C2 tumors have higher YAP1 expression, proliferation ability, and stem markers than that of C1 tumors.392 Smith et al. indicated that conditional expression of YAP1 cooperating with constitutive expression of β-catenin remolded the chromatin structure and drove the formation of hepatoblastoma in vivo, which can mimic the subtypes of human pediatric hepatoblastoma.393 In mouse hepatoblastoma model, Rodríguez et al. found that the accessibility of multiple tumor-related cis-regulatory elements had changed in a H3K27ac dependent manner.