ARID1A and Insulin resistance: ChIP-seq indicated that the ARID1A binding peaks were significant associated with C/EBPα binding peaks, H3K27ac and H3K4me3 modification in the promoters of most upregulated genes.432 Additionally, Qu et al. reported that hepatocyte-specific deletion of ARID1A significantly increased the susceptibility of hepatic steatosis, insulin resistance, and inflammation response in HFD-feeding mice.