It increased the accessibility and transcription of cccDNA by competitively combining with H1 and promoting H3 phosphorylation, respectively.95 As the most frequently integrated viral gene, HBx plays an important role in HCC pathogenesis which partial through remolding the epigenetic modification.438 Zheng et al. indicated that HBx/ETV4/DVL2/β-catenin axis promoted the migration and invasion of HCC cells. Here, ETV4 is linked to hepatocellular carcinoma.