The SWI/SNF complexes can promote or suppress cancer development by binding with different cofactors.348 ARID1A is originally hypothesized to be an anti-cancer gene, for it’s the most frequently mutated SWI/SNF component in cancer.349 Sun et al. demonstrated that ARID1A has dual function on initiation and development of liver cancer. Here, SMARCA1 is linked to liver cancer.