Interestingly, in our experimental conditions, CXCR1/2 inhibition in the insulin resistance model (TNF-a+LAD + INS) showed a behavior close to control (CTR + INS), thus suggesting CXCR1/2-mediated ameliorations in the pathways related to glucose uptake and insulin resistance (Fig. 5G, H). This evidence concerns the gene CXCR1 and Insulin resistance.