Our results revealed the tumor-induced endothelial JAK-STAT-PIM-BCL3 axis both in vitro and in vivo, with upregulation of also Pim1 in rCap, albeit less than Pim3, whereas Pim2 was not expressed in the lung ECs (Supplementary Fig. 10a, b). The gene discussed is PIM2; the disease is neoplasm.