SPRED3 and obesity due to melanocortin 4 receptor deficiency: The 6 genes (Dgat2, Fabp4, Lipe, Lrrfip1, Spred3, and Thrsp), which were not altered in MFGR as compared to all other study groups, could be responsible for this reduction in the differentiation potential of preadipocytes from MFGR, which may be responsible for the reduced incidence of obesity compared to FFGR.