This study further explored the upstream regulators of Nedd4‐2 and demonstrated that Janus Kinase 3 (JAK3) amplified Wnt3a signalling by phospho‐inactivating Nedd4‐2, thereby suppressing the infiltration of inflammatory cells in P. gingivalis‐induced mice with periodontitis [64]. Here, WNT3A is linked to periodontitis.